职称 教授

学位 博士

政治面貌 无党派人士

邮箱 zhouyang@mail.hzau.edu.cn

研究方向 水产动物病害防控

教育经历

2005年9月-2009年7月，华中农业大学生命科学技术学院，学士

2012年5月-2013年3月，美国蒙大拿州立大学免疫与传染病系，联合培养博士

2008年9月-2013年7月，华中农业大学动物科学技术学院、动物医学院，博士

主要职历

2013年10月-2015年10月，华中农业大学水产学院，博士后

2015年10月-2021年11月，华中农业大学水产学院，副教授

2015年12月-2017年5月，美国佛罗里达大学，博士后

2021年11月-至今，华中农业大学水产学院，教授

科研成果

研究方向

主要从事水产病原菌致病机制与绿色防控技术研究。聚焦水产动物细菌性败血症，解析病原菌流行传播与耐药演化规律、感染入侵途径及免疫逃逸机制，并开发疫苗、噬菌体等“无针化”绿色防控策略。

主持和参与的科研项目：

1. 基于智能挖掘的水产病原菌噬菌体裂解酶理性设计与机制解析，湖北省自然科学基金青年A类项目（原杰出青年基金项目），2026/03-2029/03，主持，在研

2. 湖北省“青年拔尖人才”项目，2025/01-2027/12，主持，在研

3. 草鱼养殖新发疫病的流行规律与发生机制，国家重点研发计划项目子课题，2024/12-2028/11，主持，在研

4. 罗非鱼主要细菌病原免疫逃逸机制及其防控策略研究，国家自然科学基金区域创新发展联合基金，2024/01-2027/12，项目骨干，在研

5. 噬菌体多糖解聚酶对嗜水气单胞菌的作用机制研究，国家自然科学基金面上项目，2021/01-2024/12，主持，结题

6. 嗜水气单胞菌CodRS双组份系统致病机制研究，国家自然科学基金面上项目，2018/01-2021/12，主持，结题

7. 嗜水气单胞菌分泌型核酸酶介导逃逸团头鲂中性粒细胞胞外网捕杀的机制研究，国家自然科学基金青年项目，2015/01-2017/12，主持，结题

发表的科研论文：

[1] Yufan Yang, Runze Li, Qiang Zhong, Yating Guo, Renwei Wu, Huanchun Chen, Rui Zhou, Ranfeng Ye, Krystyna Dąbrowska, Tomasz K Prajsnar, Graham P Stafford, Geng Zou*, Yang Zhou*, Jinquan Li*, Zhiyong Song*. In situ gut microbiota editing: Enhancing therapeutic efficacy for bacterial colitis by compatible oral hydrogel microspheres with phages, Nature Communications, 2025, 16(1):9785.

[2] Yating Guo, Geng Zou, Anusak Kerdsin, Constance Schultsz, Can Hu, Weicheng Bei, Huanchun Chen, Jinquan Li*, Yang Zhou*, Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively, Drug Resist Update. 2024, 75:101088.

[3] Hanyu Luo, Zhihao Wu, Weiqi Fan, Hui Zeng, Jie Li, Yong-An Zhang*, Yang Zhou*, Establishment of methods for visual and rapid detection of piscine lactococcosis based on isothermal recombinase polymerase amplification, BMC Veterinary Research. 2026, 22(1):448.

[4] Dandan Wang#, Bo Zhang#, Ming Chen, Hui Zeng, Xu-jie Zhang, Yong-An Zhang*, Yang Zhou*, Comparison and evaluation of DNA vaccines against Nocardia seriolae infection in largemouth bass (Micropterus salmoides), Aquaculture, 2025, 596: 741772.

[5] Lan Yang#, Zhihao Wu#, Tian-Yu Ma, Hui Zeng, Ming Chen, Yong-An Zhang*, Yang Zhou*, Identification of ClpB, a molecular chaperone involved in the stress tolerance and virulence of Streptococcus agalactiae, Vet Res. 2024, 55(1):60.

[6] Jinjie Zhang, Jinlu Huang, Shanzhen Chen, Jing Tan, Xingyi Zhu, Yanqi Gao, Hui Zeng, Yong-An Zhang*, Yang Zhou*. Development and evaluation of the inactivated vaccine against Aeromonas schubertii in hybrid snakehead, Aquaculture, 2024, 590:741087.

[7] Qikai Chen#, Yunfei Xing#, Yan Lei, Guixiang Tong, Xiaobu Lin, Pengcheng He, Shaolin Tang, Feifei Zheng, Hui Zeng, Xinxian Wei, Yong-An Zhang*, Yang Zhou*. Genetic diversity, antibiotic resistance, and pathogenicity of Aeromonas veronii isolated from farmed largemouth bass (Micropterus salmoides) in the main aquaculture regions of China, Aquaculture, 2024, 592:741150.

[8] Zhihao Wu, Yang Liu, Yuting Hou, Yuan Chen, Zhixin Wu, Yong-An Zhang*, Yang Zhou*. Bacteriophage adhering to mucus provide protection against Aeromonas veronii infection in scaleless fish, Aquaculture, 2024, 586:740804.

[9] Yuting Hou, Zhihao Wu, Li Ren, Yuan Chen, Yong-An Zhang*, Yang Zhou*, Characterization and application of a lytic jumbo phage ZPAH34 against multidrug-resistant Aeromonas hydrophila, Front Microbiol, 2023, 14:1178876.

[10] Jihong Li, Zhihao Wu, Yuting Hou, Yong-An Zhang*, Yang Zhou*, Fur functions as an activator of T6SS-mediated bacterial dominance and virulence in Aeromonas hydrophila, Front Microbiol, 2023, 13:1099611.

[11] Jihong Li, Zhihao Wu, Changsong Wu, Dan-Dan Chen, Yang Zhou*, Yong-An Zhang*. VasH contributes to virulence of Aeromonas hydrophila and is necessary to the T6SS-mediated bactericidal effect, Front Vet Sci, 2021, 8:793458.

[12] Yang Zhou#, Kang Yan#, Chengfeng Sun, Feng Liu, Wei Peng, Huanchun Chen, Fangyan Yuan, Weicheng Bei, Jinquan Li. Binding of plasminogen to Streptococcus suis protein endopeptidase O facilitates evasion of innate immunity in Streptococcus suis, Front Microbiol, 2021, 12:694103.

[13] Jihong Li#, Shilin Ma#, Zhi Li, Wei Yu, Peng Zhou, Xiang Ye, Md. Sharifull Islam, Yong-An Zhang, Yang Zhou*, and Jinquan Li, Construction and characterization of an Aeromonas hydrophila multi-gene deletion strain and evaluation of its potential as a live-attenuated vaccine in grass carp, Vaccines, 2021, 9(5):451.

[14] Zheng-Wei Cui, Xiang-Yang Zhang, Chang-Song Wu, Yong-An Zhang, Yang Zhou*, Xu-Jie Zhang*, Membrane IgM+ plasma cells in grass carp (Ctenopharyngodon idella): Insights into the conserved evolution of IgM+ plasma cells in vertebrates, Dev Comp Immunol, 2020, 106:103613.

[15] Md Sharifull Islam, Yang Hu, Md Furkanur Rahaman Mizan, Ting Yan, Ishatur Nime, Yang Zhou*, Jinquan Li, Characterization of Salmonella phage LPST153 that effectively target most prevalent Salmonella serovars, Microorganisms, 2020, 8(7):1089.

[16] Peng Zhou^#, Xueqing Han^#, Xiang Ye, Feifei Zheng, Ting Yan, Quan Xie, Yong-An Zhang, Roy Curtiss III*, Yang Zhou*, Phenotype, virulence and immunogenicity of Edwardsiella piscicida cyclic AMP receptor protein (Crp) mutants in catfish host, Microorganisms, 2020, 8(4):517.

[17] Zhendong Qin, V Sarath Babu, Ningqiu Li, Tairan Fu, Jinquan Li, Lizhu Yi, Lijuan Zhao, Jun Li, Yang Zhou*, Li Lin*, Protective effects of chicken egg yolk immunoglobulins (IgY) against experimental Aeromonas hydrophila infection in blunt snout bream (Megalobrama amblycephala), Fish Shellfish Immunol, 2018, 78:26-34.

[18] Quan Xie, Wen Mei, Xiang Ye, Peng Zhou, Md Sharifull Islam, Khalid Ragaei Abdraboh Elbassiony, Chao Yuan, Jinquan Li, Yang Zhou*, The two-component regulatory system CpxA/R is required for the pathogenesis of Aeromonas hydrophila, FEMS Microbiol Lett, 2018, 365(22).

[19] Yang Zhou^#, Xingxing Dong^#, Zhiwei Li^#, Geng Zou, Li Lin, Xiaohong Wang, Huanchun Chen, Robin B Gasser, Jinquan Li*, Predominance of Streptococcus suis ST1 and ST7 in human cases in China, and detection of a novel sequence type, ST658, Virulence, 2017, 8(6):1031-1035.

[20] Yachan Ji^#, Jinquan Li^#, Zhendong Qin, Aihua Li, Zemao Gu, Xiaoling Liu, Li Lin, Yang Zhou*, Contribution of nuclease to the pathogenesis of Aeromonas hydrophila, Virulence, 2015, 6(5):515-22.

[21] Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaoling Liu, Yang Zhou*, Li Lin*, Molecular cloning and functional characterization of mannose receptor in zebra fish (Danio rerio) during infection with Aeromonas sobria, Int J Mol Sci, 2015, 16(5):10997-11012.

[22] Yang Zhou^#, Yan Wang^#, Limei Deng, Chengkun Zheng, Fangyan Yuan, Huanchun Chen, Weicheng Bei, Jinquan Li*, Evaluation of the protective efficacy of four novel identified membrane associated proteins of Streptococcus suis serotype 2, Vaccine, 2015, 33(19):2254-2260.

[23] Xiaoling Liu^#, Xiaocheng Tang^#, Li Wang, Jie Li, Hong Wang, Shun Wei, Rui Fang, Wei Ji, Gailing Yuan, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, Yang Zhou*, Li Lin*, Molecular cloning and expression analysis of mannose receptor in blunt snout bream (Megalobrama amblycephala), Mol Biol Rep, 2014, 41(7):4601-11.

[24] Yang Zhou, Tracey S Hanks, Wenchao Feng, Jinquan Li, Guanghui Liu, Mengyao Liu, Benfang Lei*, The sagA/pel locus does not regulate the expression of the M protein of the M1T1 lineage of group A Streptococcus, Virulence, 2013, 4(8):698-706.

[25] Yang Zhou, Lu Li, Zhaohui Chen, Hong Yuan, Huanchun Chen, Rui Zhou*, Adhesion protein ApfA of Actinobacillus pleuropneumoniae is required for pathogenesis and is a potential target for vaccine development, Clin Vaccine Immunol, 2013, 20(2):287-94.

[26] 沈丹萍, 林小卜, 陈祺楷, 等. 大口黑鲈源类志贺邻单胞菌的分离鉴定及致病力研究[J/OL]. 淡水渔业, 1-14[2026-09-22].

[27] 严孟芝, 王丹丹, 杨静, 等. 大口黑鲈IL-12表达分析及异构体组成形式鉴定[J]. 水产学报, 2026, 50(1): 019103.

[28] 陈愿, 张永安, 周洋. 噬菌体在水产养殖业中的研究进展[J]. 水产学报, 2021, 45(9): 1605-1615.

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