职称 教授

邮箱 xueqinliu@mail.hzau.edu.cn

政治面貌 中共党员

研究方向 水产病毒免疫致病机理及综合防控

教育经历

2003/09-2006/06 在华中农业大学动物医学院学习，获博士学位；

1998/09-2001/06  在华中农业大学动物科技学院学习，获硕士学位；

1994/09-1998/06  在华中农业大学动物科技学院学习，获学士学位。

主要职历

2017/01-至今，  华中农业大学，水产学院，教授

2010/01-2016/12  华中农业大学，水产学院，副教授

2013/02-2014/02  美国佐治亚大学，兽医学院访问学者

2007/03-2008/05  美国夏威夷大学，公共卫生学院访问学者

2006/07-2009/12  华中农业大学，水产学院，讲师

科研成果

主持和参与的科研项目：

1. 国家自然科学基金面上项目，鲤春病毒血症病毒诱导细胞焦亡的分子机制研究（32173018），2022.01-2025.12，直接经费58万，主持。

2. 国家自然科学基金面上项目，SVCV通过泛素化降解Viperin_sv1实现免疫逃逸的分子机制（31972834），2020.01-2023.12，直接经费58万，主持。

3. 华中农业大学校自主创新基金，克氏原螯虾主要致病菌噬菌体的筛选及应用（2662018YJ022），2018.01-2020.12，30万元，主持。

4. 华中农业大学校自主创新基金，团头鲂、鳜鱼、黄颡鱼主要病原性疾病快速诊断技术的研究（2013PY071），2013.01-2015.12，20万元，主持。

5. 国家自然科学基金面上项目，鲤春病毒血症病毒诱导细胞自噬的发生及其分子机理（31172433），2012.01-2015.12，62万元，主持。

7. 国家科技支撑计划子课题，斑点叉尾鮰健康养殖与质量安全保障技术研究（2012BAD25B06），2012.01-2016.12，30万元，主持。

8. 华中农业大学校自主创新基金，鲤春病毒血症病毒诱导细胞自噬的分子机理（2011PY121），2011.01-2012.12，15万元，主持。

9. 国家自然科学基金青年项目，基于SVCV/G的假型杆状病毒构建及其在鱼用疫苗研究中的应用（30901118），2010.01-2012.12，20万元，主持。

10.湖北省自然科学基金项目，斑点叉尾鮰病毒ELISA抗体检测方法的建立（2008CBB099），2009.01-2010.12，2万元，主持。

11.教育部新教师基金项目，斑点叉尾鮰病毒“自杀性”DNA疫苗研究（20070504047）。2008.01-2010.12，3.6万元主持。

发表的科研论文：

1. Yujun Zhang, Gao Yan, Li Chen, Zhang Yongan, Lu Yuanan, Ye Jing*, Liu Xueqin*. Parabacteroides distasonis regulates the infectivity and pathogenicity of SVCV at different water temperatures. Microbiome,2024

2. Zhang Wenyan, Li Chen, Zhang Yujun, Lu Yuanan, Liu Xueqin*. Study on the inhibitory effect of rocaglamide against Micropterus salmoides rhabdovirus (MSRV), Aquaculture,2023,574: 739710

3. Li Chen, Zhang Wenyan, Shi Lin, Lu Yuanan, Ye Jing, Liu Xueqin*. Prohibitin mediates the cellular invasion of spring viremia of the carp virus. Fish and Shellfish Immunology.2023,135, 108689

4. Shi Lin, Li Chen, Gao Yan, Ye Jing, Lu Yuanan, Liu Xueqin*. STUB1 activates antiviral response in zebrafish by promoting the expression of RIG-I. Fish and Shellfish Immunology, 2022, 182-193.

5. Qin Yinghui, Liu Jiaoyun, Lu Yuanan, Liu Xueqin*. Generation and Characterization of Monoclonal Antibodies Against Red-Spotted Grouper Nervous Necrosis Virus (RGNNV). Journal of Ocean University of China. 2022 21:1061-1067.

6. Gao Yan, Xiang Yuhang, Wang Fang, Ye Jing, Lu Yuanan, Ashraf U, Liu Xueqin*. The N protein of spring viremia of carp virus promotes the ubiquitination and degradation of viperin_sv1 to escape from the fish innate immunity. Aquaculture, 2021, 538.

7. Gao Yan, Xiang Yuhang, Li Chen, Ye Jing, Lu Yuanan, Ashraf Usama, Liu Xueqin*. TRIM33 promotes spring viremia of carp virus replication by degrading the antiviral protein viperin_sv1. Aquaculture, 2021, 542. Liu Jiaoyun, Qin Yinghui, Yan Liming, Liu Wanmeng, Shi Herong, Lu Yuanan, Liu Xueqin*, Protective effects of egg yolk immunoglobulins (IgY) on juvenile grouper (Epinephelus fuscoguttatus × Epinephelus lanceolatus) from red-spotted grouper nervous necrosis virus infection. Aquaculture. 2021,545, 737218.  

8. Qin Yinghui, Wang Yixin, Liu Jiaoyun, Lu Yuanan, Liu Xueqin*. Red-grouper nervous necrosis virus B2 protein negatively regulates fish interferon response by suppressing host transcription directed by RNA polymerase II. Aquaculture, 2021, 536:736488.

9. Gao Yan, Li Chen, Shi Lin, Wang Fang, Ye Jing, Lu Yuanan, Liu Xueqin*. Viperin_sv1 promotes RIG-I expression and suppresses SVCV replication through its radical SAM domain. Developmental and Comparative Immunology, 2021, 123, 104166.

10.Li Chen, Shi Lin, Gao Yan, Lu Yuanan, Ye Jing *, Liu Xueqin*. HSC70 inhibits spring viremia of carp virus replication by inducing MARCH8-mediated lysosomal degradation of G protein. Frontiers in Immunology, 2021, 12, 724403.

11.Chen Bo#, Li Chen#, Yao Jian, Shi Ling, Liu Wanmeng, Wang Fang, Huo Shitian, Zhang Yongan, Lu Yuanan, Ashraf Usama, Ye Jing*, Liu Xueqin*. Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-κB. the Journal of Immunology. 2020, 204:1881-1891. Huo Shitian#, Jiao Houqi#, Chen Bo, Kuang Ming, Li Qing, Lu Yuanan, Liu Xueqin*. FTR67, a member of the fish-specific finTRIM family, triggers IFN pathway and against spring viremia of carp virus. Fish & shellfish immunology. 2020, 103:1-8.

12.Yao Jian, Li Chen, Shi Ling, Lu Yuanan, Liu Xueqin*. Zebrafish ubiquitin-specific peptidase 5 (USP5) activates interferon resistance to the virus by increase the expression of RIG-I. Gene. 2020, 751:144761

13.Qin Yinghui, Liu Jiaoyun, Liu Wuanmeng, Shi Herong, Jia Aiqing, Lu Yuanan, Liu Xueqin*. First isolation and identification of red-grouper nervous necrosis virus (RGNNV) from adult hybrid Hulong grouper (Epinephelus fuscoguttatus × Epinephelus lanceolatus) in China. Aquaculture. 2020, 529:735662.

14.Liu Wanmeng, Chen Bo, Li Chen, Yao Jian, Liu Jiaoyun, Kuang Ming, Wang Fang, Wang Yeda, Elkady Gehad, Lu Yuanan, Zhang Yongan, Liu Xueqin*. Identification of fish CMPK2 as an interferon stimulated gene against SVCV infection. Fish & shellfish immunology. 2019, 92:125-132.

15.Liu Wanmeng#, Kuang Ming#, Zhang Ze, Lu Yuanan, Liu Xueqin*. Molecular Characterization and Expression Analysis of ftr01, ftr42, and ftr58 in Zebrafish (Danio rerio). Virologica Sinica. 2019, 34:434-43.

16.Wang Fang, Jiao Houqi, Liu Wanmeng, Chen Bo, Wang Yeda, Chen Buxin, Lu Yuanan, Su Jianguo, Zhang Yongan, Liu Xueqin*. The antiviral mechanism of Viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells. Fish and Shellfish Immunology. 2019, 86:805-813.

17.Chen Bo, Huo Shitian, Liu Wanmeng, Wang Fang, Lu Yuanan, Xu Zhen, Liu Xueqin*. Fish-specific finTRIM FTR36 triggers IFN pathway and mediates inhibition of viral replication. Fish and Shellfish Immunology. 2019, 84: 876-884.

18.Chen Buxin, Li Chen, Wang Yeda, Lu Yuanan, Wang Fang, Liu Xueqin*. 14-3-3β/α-A interacts with glycoprotein of spring viremia of carp virus and positively affects viral entry. Fish and Shellfish Immunology.2018, 81: 438-444.

19.Wang Yeda, Zhang Hao, Lu Yuanan, Wang Fang, Liu Liyue, Liu Jingxia, Liu Xueqin*. Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Fish and Shellfish Immunology, 2017, 69:35-45.

20.Wang Yeda, Kuang Ming, Lu Yuanan, Lin Li, Liu Xueqin*. Characterization and biological function analysis of the TRIM47 gene from common carp (Cyprinus carpio). Gene, 2017, 627:188-193.

21.Ashraf Usama, Lu Yuanan, Lin Li, Yuan Junfa, Wang Min, Liu Xueqin*. Spring viremia of carp virus: recent advances. Journal of General Virology, 2016, 97:1037-1051.

22.Wang Yeda, Li Zeming, Lu Yuanan, Hu Guangfu, Lin Li, Zeng Lingbing, Zhou Yong, Liu Xueqin*. Molecular characterization, tissue distribution and expression, and potential antiviral effects of TRIM32 in the common carp (Cyprinus carpio). International Journal of Molecular Sciences, 2016, 17(10):1693.

23.Liu Liyue#, Zhu Bibo#, Wu Shusheng, Lin Li, Liu Guangxin, Zhou Yang, Wang Weimin, Asim Muhammad, Yuan Junfa, Li Lijuan, Wang Min, Lu Yuanan, Wang Huanling, Cao Jianbo, Liu Xueqin*. Spring viremia of carp virus induces autophagy for necessary viral replication. Cellular Microbiology, 2015, 17(4): 595-605.

24.Wu Shusheng, Liu Liyue, Ali Zohaib, Lin Li, Yuan Junfa, Wang Min, Liu Xueqin*. MicroRNA profile analysis of epithelioma papulosum cyprini cell line before and after SVCV infection. Developmental and Comparative Immunology, 2015, 48:124-128.

25.Li Zeming, Zhang Qi, Luo Peixiao, Liu Guangxin, Wang Min, Liu Xueqin*. Monoclonal antibody against M protein of spring viremia of carp virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2015, 34(2):122-125.

26.Luo Peixiao, Ruan Xindi, Zhang Qi, Li Zeming, Wang Min, Liu Xueqin*. Monoclonal antibodies against G protein of spring viremia of carp virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2014, 33(5): 340-343.

27.Liu Liyue, Li Qin, Lin Li, Wang Min, Lu Yuanan, Wang Weimin, Yuan Junfa, Li Lijuan, Liu Xueqin*. Proteomic analysis of epithelioma papulosum cyprini cells infected with spring viraemia of carp virus. Fish and Shellfish Immunology, 2013, 35(1): 26-35.

28.Huang Fengtao, Li Qin, Cui Xiaoxian, Cao Shengbo, Xiong Chuanxi, Wang Min, Lu Yuanan, Wang Weimin, Ye Jing, Liu Xueqin*, Characterization of Spring Viremia of Carp Virus Glycoprotein Expressed by Recombinant Baculovirus, Pakistan Veterinary Journal, 2012, 32(3) :334-338

29.Huang Fengtao#, Cao Shengbo#, Cui Xiaoxian, Xiong Chuanxi, Wang Min, Lu Yuanan, Wang Weimin, Ye Jing, Liu Xueqin*, Efficient gene delivery into fish cells by an improved recombinant baculovirus, Journal of Virological Methods, 2011,173:294-299

30.曾荣博,刘爽,张玉军,李陈,余艳枝,李元平,肖运才,刘学芹*.抗大口黑鲈弹状病毒发酵中草药的筛选及其效果评价.水生生物学报,2024,48(03):479-487.

31.章文言,张玉军,李陈,石和荣, 刘学芹*.大口黑鲈弹状病毒的分离与鉴定.华中农业大学学报,2022,41(06):230-236.

32.焦厚琪,霍诗天,闫黎明,李艳和,刘学芹*.克氏原螯虾一种新型甲壳素基因的鉴定和抑菌功能研究.水生生物学报,2022,46(02):248-256.

33.霍诗天,焦厚琪,李清,兰江风,顾泽茂,刘学芹*.克氏原螯虾副溶血弧菌的分离鉴定及药敏特性.水生态学杂志,2022,43(01):124-129.

34.姚健,王业大,王方,柳力月,鲁元安,刘学芹*.敲除trim47基因斑马鱼脑和脾的比较转录组学分析（英文）.水生生物学报,2021,45(03): 496-506.

35.霍诗天,焦厚琪,李清,顾泽茂,刘学芹*.克氏原螯虾嗜水气单胞菌噬菌体的分离鉴定和应用.水生生物学报,2021,45(02):366-375

36.邝鸣,刘晥蒙,姚健,霍诗天,刘学芹*.斑马鱼ftr56基因克隆表达及功能研究.水生生物学报,2020,44(01):20-25

37.王方, 彭俊杰, 王业大, 刘学芹*. 鲤春病毒血症病毒核蛋白原核表达及单克隆抗体制备. 华中农业大学学报, 2017, 36(03):79-85.

38.贾路路,曾令兵,王方,彭俊杰,王业大,周勇,刘学芹*.草鱼TRIM32基因克隆表达及功能研究.水生生物学报,2017,41(04):741-747.

39.彭俊杰,张琪,贾路路,林蠡,袁军法,曾令兵,周勇,刘学芹*.鲤疱疹病毒Ⅱ型(CyHV-2) ORF25蛋白的原核表达及单克隆抗体的制备.华中农业大学学报,2017,36(02):96-101.

40.罗培骁, 张琪, 王敏, 刘学芹*. 鲤春病毒血症病毒G蛋白的原核表达及多克隆抗体的制备. 水生态学杂志, 2014, 35(4):81-86.

授权和申请专利：

1. 刘学芹, 刘皖蒙,刘焦云,姚健,王业大,王方, 陈博.一种分离的鱼类抗病毒蛋白基因CMPK2及其抗病毒活性, 2020-11-13, ZL201811217731.6.

2. 刘学芹, 张琪,李泽明,罗培骁,彭俊杰,贾路路,王业大.抗斑点叉尾鮰病毒囊膜蛋白ORF46的单克隆抗体及其应用,中国, ZL201510003012.4,2018.1.12.

3. 刘学芹,李泽明,张琪,王业大,袁军法,贾路路,吴术盛,彭俊杰.分离的鲤抗病毒天然免疫蛋白TRIM32及抗病毒活性, ZL201510027522.5,2017.12.19,

4. 刘学芹, 刘广鑫, 林蠡, 袁军法, 李泽明, 柳力月, 罗培骁.一种鳜鱼传染性脾肾坏死病毒的LAMP检测方法，ZL 2014101182564,2016.1.6

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